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Grade 2 or 3 non-haematological toxic events attributed to rigosertib
| Rigosertib b.i.d. dosing | 560 mg (n=24) | 700 mg (n=6) | ||
|---|---|---|---|---|
| Grade 2 | Grade 3 | Grade 2 | Grade 3 | |
| Dysuria | 4 | 1 | 3 | 1 (DLT) |
| Haematuria | 4 (1 SAE) | 1 | 1 | 1 |
| Urinary Frequency | 0 | 1 | 0 | 0 |
| Nocturia | 0 | 0 | 1 | 0 |
| Cystitis | 0 | 0 | 1 | 0 |
| Diarrhoea | 1 | 1 | 0 | 0 |
| Abdominal pain | 0 | 1 (SAE) | 0 | 0 |
| Hypotension, syncope | 0 | 0 | 0 | 1 (SAE) |
| Shortness of breath | 0 | 0 | 0 | 1 (DLT) |
| Fatigue | 1 | 1 | 0 | 0 |
| Anorexia | 0 | 0 | 1 | 0 |
DLT, dose-limiting toxicity; SAE, severe adverse event.
