. Author manuscript; available in PMC: 2016 Jul 7.

Published in final edited form as: Phys Med Biol. 2015 Jun 17;60(13):5083–5101. doi: 10.1088/0031-9155/60/13/5083

Table 6.

Acquisition parameters and observer performance for the optimized and clinical dual isotope protocols.

	Optimized protocol		Clinical protocol
Acquisition type:	Simultaneous	Separate^b	Separate
Acquisition parameters:
(a) Injected activities (mCi):
Tc-99m	5.9–10^a	5.9–18.2^a	30
Tl-201	2–2.25^a	1.5–2.25^a	3
Relative injected activity	2.6–5^a	2.6–12.1^a	10
Total effective dose (mSv)	13.5	13.5	27.5
(b) Energy window width (%):
Tc-99m	20	20	20
Tl-201	16.6–22.2^a	11.1–22.2^a	27.8
2-class IO performance:
(a) Rest and stress image qualities
Rest Tl-201	0.819	0.751	0.792
Stress Tc-99m	0.938	0.951	0.953
(b) Pairwise comparison between the 3 classes
Normal Versus Fixed	0.949	0.960	0.961
Normal Versus Reversible	0.919	0.944	0.947
Reversible Versus Fixed	0.892	0.862	0.875
3-class IO performance:
VUS	0.805 ± 0.01	0.809 ± 0.01	0.824 ± 0.008

Range of optimal acquisition parameter.

Note the dependence of optimal Tl-201 injected activity, (and thus Tc-99m activity) and Tl-201 energy window width.