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HMGB1 structure. HMGB1 structure with the A and B box-binding regions as well as the acidic tail. The TLR4 and RAGE4-binding regions are also highlighted. The three cysteine residues are apparent at the 23, 45, and 106 positions. HMGB1, high-mobility group box protein 1; RAGE, receptor for advanced glycation end-products; TLR4, toll-like receptor 4. To see this illustration in color, the reader is referred to the web version of this article at www.liebertpub.com/ars
