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Forms of RAGE. The RAGE receptor can be found in several forms throughout the organism due to splicing variations. (A) Full-length RAGE is the most prominent isoform of the receptor. (B) A soluble form of the receptor exists without the transmembrane domain, signaling domain, or C-Terminus. (C) Inert RAGE receptors can be found with modifications to the signaling domain, preventing signal transduction down the pathway.
