FIG. 7.

Predicted dynamics of Th1 and Th2 cells in mouse models of acute inflammation. A differential equation model of acute inflammation was modified to include DC, Th1 cells, and Th2 cells. The model was partially calibrated against trajectories of TNF-α, IL-6, IL-10, and NO₂⁻/NO₃⁻ obtained from C57Bl/6 mice subjected to endotoxemia (A), surgical cannulation trauma (B), or surgical cannulation+hemorrhagic shock (C). Predicted trajectories of Th1 and Th2 cells are shown for the three inflammatory scenarios. To see this illustration in color, the reader is referred to the web version of this article at www.liebertpub.com/ars