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. 2015 Dec 1;28(6):411–422. doi: 10.1089/jamp.2015.1241

Fig. 5.

Fig. 5.

The effect of nebulization on the IVR profile. The control CFI formulation (at 50 mg/mL) and each of the 12.5 mg/mL CFI formulations were diluted to 50 μg/mL CFI in HEPES buffered saline (HBS) prior to a 1:1 dilution in bovine serum to measure the release of ciprofloxacin after incubation at 37°C for up to 4 h. (A) IVR profiles for Control CFI (black circles), CFI in 90 mg/mL sucrose, 0.1% polysorbate 20, pH 5.3, before nebulization (gray squares) or after nebulization (gray triangles). (B) IVR profiles for Control CFI (black circles), CFI in 90 mg/mL sucrose, 0.1% polysorbate 20, pH 4.9, before nebulization (gray squares) or after nebulization (gray triangles). The error bars that are not visible are smaller than the width of the data symbols.