Table 4.

Vesicle Size at Room Temperature Storage after Freeze-Thaw of Four pH-Adjusted 12.5 mg/mL CFI Formulations^*

	Mean vesicle size (nm)**
	Time (weeks)
Formulation	0	0.4	1.4	2.3	3.4	5.3
Unfrozen CFI	ND	89.2	ND	89.7	90.7	90.6
pH 5.9	98.5	104.0	109.8	106.6	109.0	104.8
pH 5.3	103.8	108.2	114.8	110.0	108.8	108.7
pH 4.9	103.4	110.0	117.5	111.1	112.8	111.6
pH 4.6	103.9	107.6	117.7	113.1	113.1	113.5

^*Formulations contain 90 mg/mL sucrose and 0.1% polysorbate 20.

^**The vesicle size data are reported as the mean (in nm). ND, not determined.