Table 4.
Mean vesicle size (nm)** | ||||||
---|---|---|---|---|---|---|
Time (weeks) | ||||||
Formulation | 0 | 0.4 | 1.4 | 2.3 | 3.4 | 5.3 |
Unfrozen CFI | ND | 89.2 | ND | 89.7 | 90.7 | 90.6 |
pH 5.9 | 98.5 | 104.0 | 109.8 | 106.6 | 109.0 | 104.8 |
pH 5.3 | 103.8 | 108.2 | 114.8 | 110.0 | 108.8 | 108.7 |
pH 4.9 | 103.4 | 110.0 | 117.5 | 111.1 | 112.8 | 111.6 |
pH 4.6 | 103.9 | 107.6 | 117.7 | 113.1 | 113.1 | 113.5 |
Formulations contain 90 mg/mL sucrose and 0.1% polysorbate 20.
The vesicle size data are reported as the mean (in nm). ND, not determined.