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. 2015 Dec 21;5:285. doi: 10.3389/fonc.2015.00285

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Copyright © 2015 de Groot, Hsia, Anzola, Motamedi, Yoon, Wong, Jenkins, Lee, Martinez, Davis, Gahman, Desai and Shiau.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Chemical structures of Aurora kinase inhibitors analyzed in this study. The chemical structures of the 10 commercially available compounds characterized in this study are depicted (see Table S1 in Supplementary Material for suppliers). Outlined boxes group chemically related inhibitors: Pyrazolo-pyrimidine class (Vertex/Merck/Banyu) – MK-5108 and MK-8745 were derived from VX-680 (orange outlined box); Benzazepine class (Millenium/Takeda) – MLN8237 was derived from MLN8054 (gray outlined box); and Quinazoline class (Astra Zeneca) – AZD1152-HQPA was derived from ZM447439 (blue outlined box).