Fig.1.

Different applications of pHLIP for targeting of acidic tissues. Tethering of cargo molecules to the surface of cells (a). Cytoplasmic delivery of cargo molecules and it's release by break of cleavable link (shown in blue) (b). Assembly of multifunctional pHLIP-coated liposomes containing polar (green) and hydrophobic (yellow) payloads (c). Schematic presentation of interactions of lipid bilayer of the pHLIP-coated multifunctional liposomes with plasma membrane of a cell (presentation of liposome in the endosome is schematic and not in a scale) (d).