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. 2015 Aug 20;11(11):2705–2715. doi: 10.1080/21645515.2015.1019186

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Published with license by Taylor and Francis Group, LLC

This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.

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Figure 6. — DNA/Ad and AdCA trials: association of fold changes of antibody responses to CSP and AMA1 with pre-CHMI activities. The associations of fold-changes of pre-CHMI and post-CHMI activities with pre-CHMI activities are shown as log-transformed values, and the dotted line represents no-change. (A) DNA-Ad trial: AMA1: there was no relationship between fold change after CHMI and pre-CHMI activities. (B) AdCA trial: CSP: there was a significant relationship between fold change after CHMI and pre-CHMI activities. (C): AdCA trial: AMA1: there was a stronger significant relationship than CSP between fold change and pre-CHMI activities. In the AdCA trial, CHMI had a greater effect on lower than higher pre-CHMI activities, and for AMA1, CHMI greatly increased pre-CHMI activities.