Table 1.

Clinical characteristics of Familial Hypercholesterolemic (FH) swine.

Variables	Control	n	14 Months	n	24 Months	n
Body weight (kg)	72.0 ± 2.0	5	66.6 ± 2.9	15	110.6 ± 13.2†	10
Body fat (%)	NA	0	26.2 ± 1.5	7	27.3 ± 4.7	5
Glucose (mg/dL)	99.2 ± 3.2	0	112.1 ± 7.9	15	119.1 ± 15.1	10
Triglyceride (mg/dL)	16.4 ± 2.8	5	42.7 ± 6.3*	15	85.7 ± 7.6*†	7
Cholesterol (mg/dL)	85.6 ± 5.3	5	344.8 ± 19.6*	15	528.4 ±52.7*†	7
LDL cholesterol (mg/dL)	50.4 ± 4.6	5	270.3 ± 17.9*	15	465.0 ± 51.2*†	7
HDL cholesterol (mg/dL)	46.0 ± 1.0	5	44.2 ± 1.6	15	36.4 ± 3.0*†	7

Values for FH swine were compared to those measured in five non-FH domestic swine (control). Data are means ± SE.

^*P < 0.05 vs. control;

^†P < 14 vs. 24 month-old pigs. FH pigs had greater plasma triglycerides, LDL- and total cholesterol compared to control swine, whereas only 24 month-old FH pigs had lower HDL cholesterol. Body weight, cholesterol, triglyceride and LDL were increased and HDL decreased in 24- vs 14-month old Percent body fat and glucose were not significantly different between both FH groups. NA, not available; LDL indicates low-density lipoprotein cholesterol; HDL, high-density lipoprotein cholesterol.