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. Author manuscript; available in PMC: 2015 Dec 21.
Published in final edited form as: Compr Physiol. 2011 Apr;1(2):971–993. doi: 10.1002/cphy.c100053

Figure 4.

Figure 4

Localization of the kallikrein-kinin system along the nephron. Kallikrein is produced in the convoluted connecting tubule, kininogens in the cortical portion of the collecting duct and kinins along the collecting duct. Filtered blood kinins are mainly destroyed by kininases located along the proximal tubule. Activation of kinin receptors in the nephron leads to production of prostaglandin E2 (PGE2) along the medullary portion of the collecting duct. Drawing of the nephron was kindly provided by Dr. William H. Beierwaltes.