Figure 7.

Antihypertensive effect of ACE inhibitor in bradykinin B2 receptor knockout (−/−) mice. Mice with 2K-1C hypertension were given plain water (vehicle) or water mixed with ACE inhibitor, ramipril, (4 mg/kg/day) to drink 5 weeks after blood pressure was increased. ACE inhibitor normalized blood pressure in B2−/− hypertensive mice. *P < 0.001, 2K-1C versus sham; **P < 0.001, 2K-1 C versus 2K-1C + ramipril. (Rhaleb N-E and Carretero O.A. unpublished data.)