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Role of kinins in the acute antihypertensive effects an ACE inhibitor (enalaprilat) in rats with severe hypertension. Top: Blood kinin concentrations before (C) and after administration of the ACE inhibitor. Bottom: Mean blood pressure before and after ACE inhibition, open and closed circles represent rats pretreated with a kinin antagonist or vehicle, respectively. Values are mean ± SEM (bottom). [Reprinted from Carbonell et al. (40).]
