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. 2015 Dec 11;11:2557–2576. doi: 10.3762/bjoc.11.276

Table 2.

Previous reports on the copper-catalyzed Huisgen cycloaddition to bistriazoles with spacers.

Cu source Solvent Spacer Alkyne Application
Cu(OAc)2, sodium ascorbate
[69]		 H2O/t-BuOH graphic file with name Beilstein_J_Org_Chem-11-2557-i041.jpg graphic file with name Beilstein_J_Org_Chem-11-2557-i042.jpg Complexation
CuI
[70–71]		 THF/H2O graphic file with name Beilstein_J_Org_Chem-11-2557-i043.jpg graphic file with name Beilstein_J_Org_Chem-11-2557-i044.jpg Chemical sensor
CuSO4·5H2O,
sodium ascorbate
[72]		 DMF/H2O graphic file with name Beilstein_J_Org_Chem-11-2557-i045.jpg graphic file with name Beilstein_J_Org_Chem-11-2557-i046.jpg Supermolecular chemistry
CuSO4·5H2O,
sodium ascorbate
[73]		 DMF graphic file with name Beilstein_J_Org_Chem-11-2557-i047.jpg graphic file with name Beilstein_J_Org_Chem-11-2557-i048.jpg Cytotoxic activity
[74] CHCl3 graphic file with name Beilstein_J_Org_Chem-11-2557-i049.jpg graphic file with name Beilstein_J_Org_Chem-11-2557-i050.jpg Polymer chemistry
CuSO4·5H2O,
sodium ascorbate
[75]		 THF/H2O graphic file with name Beilstein_J_Org_Chem-11-2557-i051.jpg graphic file with name Beilstein_J_Org_Chem-11-2557-i052.jpg –
CuSO4·5H2O,
sodium ascorbate
[76]		 H2O/t-BuOH graphic file with name Beilstein_J_Org_Chem-11-2557-i053.jpg graphic file with name Beilstein_J_Org_Chem-11-2557-i054.jpg DNA binding
CuSO4·5H2O,
sodium ascorbate
[77]		 THF/H2O graphic file with name Beilstein_J_Org_Chem-11-2557-i055.jpg graphic file with name Beilstein_J_Org_Chem-11-2557-i056.jpg Receptor
CuSO4·5H2O,
sodium ascorbate
[78]		 DMF/H2O graphic file with name Beilstein_J_Org_Chem-11-2557-i057.jpg graphic file with name Beilstein_J_Org_Chem-11-2557-i058.jpg Molecular recognition
Cu(OAc)2/Cu
[79]		 DMSO graphic file with name Beilstein_J_Org_Chem-11-2557-i059.jpg graphic file with name Beilstein_J_Org_Chem-11-2557-i060.jpg Fluorescence brightening agents
CuSO4/Cu
[80]		 EtOH graphic file with name Beilstein_J_Org_Chem-11-2557-i061.jpg graphic file with name Beilstein_J_Org_Chem-11-2557-i062.jpg Chemical sensor
CuI
[81]		 CH2Cl2/MeOH graphic file with name Beilstein_J_Org_Chem-11-2557-i063.jpg graphic file with name Beilstein_J_Org_Chem-11-2557-i064.jpg Electroactive receptor
Cu(OAc)2
sodium ascorbate
[82]		 t-BuOH graphic file with name Beilstein_J_Org_Chem-11-2557-i065.jpg graphic file with name Beilstein_J_Org_Chem-11-2557-i066.jpg Biological activity