Table 2.
Pregnancy outcome | Placebo | DMFa | Glatiramer acetate | Blinded therapy | Discontinued DMFb | Total |
---|---|---|---|---|---|---|
Total number of women who became pregnant | 13 | 42c | 4 | 1 | 3 | 63 |
Live birth | 9 | 26 | 1 | 0 | 1 | 37 |
Spontaneous abortion | 2 | 3d | 0 | 0 | 0 | 5 |
Elective termination | 2 | 10e | 2 | 0 | 0 | 14 |
Pregnancy ongoing | 0 | 2 | 0 | 1 | 2 | 5 |
Lost to follow-up | 0 | 1 | 1 | 0 | 0 | 2 |
aDelayed-release DMF (also known as gastro-resistant DMF); DMF dimethyl fumarate
bSubjects had discontinued DMF for >60 days at the time of their last menstrual period
cPatients from the pregnancy registry are not included in this analysis
dOne subject who had a spontaneous abortion at 11 weeks gestational age had discontinued DMF 240 mg three times a day 4 months earlier and was taking interferon beta-1a until 6 weeks gestational age
eOne elective termination was in the setting of abnormalities detected on ultrasound at least 1 month after the patient discontinued DMF