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Mechanism of action of tafamidis binding to thyroxin-binding sites at the transthyretin tetramer preventing dissociation into misfolded monomers and formation of fibrils and amyloid. a Tafamidis prevents dissociation into misfolded monomers and formation of amyloid fibrils. b Amyloid deposits in peripheral nerves in different tissue stainings (H&E, Gomori trichrome and Congo red)
