Table 1.
Biodistribution and physical radiation doses following intracerebral (i.e.) administration of N5-2OH to F98 glioma bearing rats
| Boron uptake (μg/g)c |
Physical dose (Gy)e |
|||||
|---|---|---|---|---|---|---|
| Groupa | Tumorb | Braind | Blood | Tumor/Brain Ratio | Tumor | Brain |
| F98/i.c. N5-2OH | 17.3±4.3 | <0.5 | <0.5 | 34.6 | 5.7 | 1.9 |
| F98/i.c. N5-2OH + i.v. BPA | 28.0±4.5 | 4.0±1.3 | 5.5±1.5 | 7.0 | 8.2 | 2.7 |
| F98/i.v. BPA | 10.7±1.7 | 3.8±1.1 | 5.2±1.3 | 2.8 | 4.2 | 2.6 |
| F98/Irradiation control (i.c. of DMSO) | None | None | None | -- | 1.8 | 1.8 |
10B enriched N5-2OH was administered over 24 hr i.c. by means of ALZET® pumps at a flow rate of 8.33 μL/hr. BPA was administered intravenously 2.5 hr prior to BNCT.
F98 glioma cells were implanted into rats intracerebrally. The rats were irradiated 14 days after implantation.
Boron content was quantified by means of direct current plasma-atomic emission spectroscopy (DCP-AES). Boron uptake was present percent injected dose per gram tissue (ID%/g)
Boron concentrations for the tumor bearing cerebral hemisphere after excision of the tumor.
Physical dose estimates include contributions from γ photons, 14N (n,p)14C and 10B (n,α) 7Li reactions.