Skip to main content
. Author manuscript; available in PMC: 2017 Jan 1.
Published in final edited form as: Immunol Rev. 2016 Jan;269(1):76–84. doi: 10.1111/imr.12383

Table 1.

Properties and phenotypes of knock out mice with a focus on the role of TLR7 in health and disease

Candidate Chromosome in
humans		 Location Phenotype of
KO		 reference
TLR9 3p21 Endosomes More severe disease in autoimmune mice (57)
TLR7 Xp22, one inactive copy in female cells Endosomes Attenuation of disease in and autoimmune mice (14)
UNC93B1 11q13 Endosomes Manifestations of disease (12, 13)
Ro60 1q31 Diffuse at cytoplasmic and nuclear sites Manifestation of disease (23)