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. Author manuscript; available in PMC: 2015 Dec 21.
Published in final edited form as: IEEE Trans Ultrason Ferroelectr Freq Control. 2015 Dec;62(12):2068–2078.

Fig. 5.

Fig. 5

Lesion development within the reference zone over 500 histotripsy pulses. Each curve shows the mean ± SD over eight treatments. (A) The low PRF of 1 Hz produced lesions with a relatively high per-pulse efficiency. (B) At the much higher PRF of 100 Hz, lesion generation showed a reduction in per-pulse efficiency. (C–F) With the incorporation of bubble removal sequences, the efficiency of lesion development at the high PRF of 100 Hz was improved, more closely approximating that observed at the low pulse rate of 1 Hz. Optimal lesion development was observed with the incorporation of a 1000 cycle bubble removal sequence, which produced a per-pulse efficiency exceeding that observed at 1 Hz.