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. Author manuscript; available in PMC: 2015 Dec 21.
Published in final edited form as: IEEE Trans Ultrason Ferroelectr Freq Control. 2015 Dec;62(12):2068–2078.

Fig. 6.

Fig. 6

Lesion development within the peripheral zone over 500 histotripsy pulses. Each curve shows the mean ± SD over eight treatments. (A) The low PRF of 1 Hz produced lesions with minimal peripheral zone damage. (B) At the much higher PRF of 100 Hz, the extent of damage observed in the peripheral zone increased substantially. (C–F) With the incorporation of bubble removal sequences, the degree of damage in the peripheral zone produced at 100 Hz PRF was reduced. Bubble removal sequences of 1000 and 5000 cycles mitigated peripheral zone damage to levels commensurate with that observed at 1 Hz.