Table III.
Drug stability results over 3 mo obtained for formulation C [1 mL of ketamine (100 mg/mL), 1 mL of xylazine (20 mg/mL), 0.3 mL of acepromazine (10 mg/mL), and 7.7 mL of sterile physiological saline]
| Time (mo) | Room temperature | ||||||||
|---|---|---|---|---|---|---|---|---|---|
|
| |||||||||
| Ketamine | Xylazine | Acepromazine | |||||||
|
|
|
|
|||||||
| % remaining | SD | %CV | % remaining | SD | %CV | % remaining | SD | %CV | |
| 0 | 100.00 | 1.78 | 1.8% | 100.00 | 2.92 | 2.9% | 100.00 | 2.92 | 2.9% |
| 1 | 103.52 | 1.08 | 1.0% | 99.53 | 0.85 | 0.9% | 93.98* | 1.74 | 1.9% |
| 2 | 104.66 | 1.34 | 1.3% | 98.61 | 0.42 | 0.4% | 88.06* | 0.32 | 0.4% |
| 3 | 102.92 | 2.28 | 2.2% | 100.18 | 2.86 | 2.9% | 82.92* | 4.23 | 5.1% |
| 4°C | |||||||||
| 0 | 100.00 | 6.12 | 6.1% | 100.00 | 1.01 | 1.0% | 100.00 | 1.01 | 1.0% |
| 1 | 95.63 | 2.62 | 2.7% | 97.90 | 1.45 | 1.5% | 95.83 | 3.20 | 3.3% |
| 2 | 94.67 | 0.74 | 0.8% | 96.38 | 0.38 | 0.4% | 93.61* | 2.77 | 3.0% |
| 3 | 97.52 | 6.30 | 6.5% | 95.68 | 2.20 | 2.3% | 91.47* | 2.10 | 2.3% |
*
Concentration remaining < 90% of initial concentration.
P < 0.0001 [one-way analysis of vaiance (ANOVA) with post-hoc Dunnett’s test].
SD — standard deviation; CV — coefficient of variation.