Table I.
Serum growth differentiation factor 11 (GDF11) concentrations and demographic characteristics of the study population
| ISACHCa | ||||
|---|---|---|---|---|
|
|
||||
| Control (n = 11) | I (n = 17) | II (n = 29) | III (n = 20) | |
| Age | ||||
| Median age (y) | 8.4 | 11.6 | 11.6 | 11.8 |
| Age range (y) | 4.3 to 11.6 | 7 to 15 | 5.7 to 16 | 7.9 to 16 |
| Mean ± SD | 8.02 ± 2.32 | 10.99 ± 2.29 | 11.31 ± 2.46 | 11.36 ± 2.30 |
| Gender | ||||
| Male (% CM) | 4 (100%) | 8 (75%) | 13 (85%) | 13 (92%) |
| Female (% SF) | 7 (86%) | 9 (78%) | 16 (75%) | 7 (57%) |
| Body weight (kg) | 4.70 ± 2.69 | 4.44 ± 1.75 | 5.21 ± 2.54 | 4.54 ± 1.25 |
| VHS | 9.77 ± 0.37 | 10.18 ± 0.53 | 11.01 ± 0.95 | 11.89 ± 1.13 |
| Transmitral E-peak | 0.66 ± 0.17 | 0.74 ± 0.18 | 0.92 ± 0.24 | 1.37 ± 0.43 |
| LA:Ao | 1.15 ± 0.09 | 1.46 ± 0.18 | 1.79 ± 0.39 | 2.45 ± 0.67 |
| LVIDd:Ao | 1.43 ± 0.14 | 1.81 ± 0.48 | 2.00 ± 0.43 | 2.78 ± 0.65 |
| sBUN (mg/dL) | 17.27 ± 6.75 | 21.46 ± 11.19 | 30.75 ± 20.47 | 36.08 ± 25.75 |
| sCreatinine (mg/dL) | 0.67 ± 0.22 | 0.78 ± 0.32 | 0.96 ± 0.46 | 1.19 ± 0.55 |
| sGDF11 (pg/mL) | 111.6 ± 135.0 | 93.8 ± 131.6 | 92.1 ± 190.4 | 98.8 ± 127.8 |
a
Data were represented as mean ± standard deviation.
ISACHC — the International Small Animal Cardiac Heart Council; CM — castrated male; SF — spayed female; VHS — vertebral heart scale; LA:Ao — left atrial to aorta ratio; LVID:Ao — left ventricular internal dimension at diastole to aorta ratio; sBUN — serum blood urea; sCreatinine — serum creatinine; GDF11 — Growth differentiation factor 11.