Table II.
Most enriched pathways in the cellular senescence-specific modules.
| Module | Pathway name | Number of genes | P-value |
|---|---|---|---|
| Blue | Cell cycle | 12 | 1.60×10−6 |
| Blue | DNA replication | 5 | 3.02×10−4 |
| Brown | Cell cycle | 7 | 1.67×10−3 |
| Brown | mTOR signaling pathway | 4 | 5.73×10−3 |
| Green | Glycolysis/Gluconeogenesis | 3 | 1.50×10−2 |
| Green | Oxidative phosphorylation | 4 | 3.45×10−2 |
| Green/yellow | Spliceosome | 4 | 2.22×10−2 |
| Green/yellow | Pentose and glucuronate interconversions | 2 | 2.41×10−2 |
| Magenta | Steroid biosynthesis | 2 | 6.38×10−3 |
| Magenta | Alzheimer's disease | 4 | 3.73×10−2 |
| Red | Proteasome | 3 | 9.40×10−3 |
| Red | Oxidative phosphorylation | 5 | 1.40×10−2 |
| Salmon | Melanoma | 3 | 9.63×10−3 |
| Salmon | Prostate cancer | 3 | 1.71×10−2 |
| Tan | Renal cell carcinoma | 3 | 1.43×10−2 |
| Tan | Rheumatoid arthritis | 3 | 2.02×10−2 |
| Turquoise | Protein processing in endoplasmic reticulum | 16 | 3.79×10−4 |
| Turquoise | PPAR signaling pathway | 10 | 5.66×10−4 |
| Yellow | Linoleic acid metabolism | 4 | 2.92×10−3 |
| Yellow | Cell cycle | 6 | 6.12×10−3 |
mTOR, mammalian target of rapamycin; PPAR, peroxisome proliferator-activated receptor.