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. 2015 Nov 23;13(1):713–719. doi: 10.3892/mmr.2015.4597

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Copyright: © Zhou et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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FGFR1 affects the cell cycle in osteosarcoma. (A) Kyoto Encyclopedia of Genes and Genomes analysis revealed that the (a) cell cycle was significantly affected in osteosarcoma (P=0.003), whereas no significant change was observed in the (b) bone remodeling process (P=0.369). (B) Heatmap analysis revealed increases in the experession of a broad spectrum of genes associated with the cell cycle, whereas the expression of other genes decreased. (C and D) Multiple cell cycle-associated genes were upregulated, while other genes were downregulated. FGFR1, fibroblast growth factor receptor 1.