Table VII.
Cytogenetic analysis with the mammalian bone marrow chromosome aberration test.
| Group | Time of sacrifice (h) | Gender | Number of animals | Total aberrations (n) | Cells with aberration (n) | Mitotic index (%) |
|---|---|---|---|---|---|---|
| CEC (2,000 mg/kg) | 18 | M | 5 | 1.20±1.10 | 1.00±1.00 | 6.06±0.20 |
| F | 5 | 2.00±0.71 | 1.40±0.55 | 6.08±0.24 | ||
| 42 | M | 5 | 1.00±1.00 | 0.60±0.55 | 5.80±0.19 | |
| F | 5 | 1.20±1.30 | 0.80±0.84 | 5.82±0.68 | ||
| Positive control (cyclophosphamide) | 18 | M | 5 | 240.60±5.32a | 52.80±6.46a | 1.90±0.27a |
| F | 5 | 237.40±7.09a | 51.60±6.27a | 1.80±0.32a | ||
| 42 | M | 5 | 216.00±9.27a | 48.00±7.58a | 1.98±0.36a | |
| F | 5 | 212.00 ±4.45a | 54.40±5.68a | 2.14±0.18a | ||
| Negative control | 18 | M | 5 | 2.20±0.84 | 1.80±0.84 | 6.38±0.28 |
| F | 5 | 2.40±0.55 | 1.80±0.84 | 6.06±0.21 | ||
| 42 | M | 5 | 2.00±0.71 | 1.20±0.45 | 6.82±0.40 | |
| F | 5 | 1.40±0.89 | 1.20±0.45 | 5.78±0.49 |
Analysis of variance was used for statistical analysis. Data are presented as the mean ± standard deviation.
a
P<0.01, compared with the negative control. CEC, curcuminoid-essential oil complex; M, male; F, female.