Fig 2. The inhibitory effect of DP on TMEM16A-CaCC activity in SW620 cells.
A, TMEM16A-CaCC currents from SW620 cells were confirmed by 100 μM NFA (left) and 10 μM T16Ainh-A01 (right). B, Representative traces from inside-out patches showing inhibition of TMEM16A-CaCC by 50 μM DP (left) and 5 μM DP (right). C, Summary of the percent of inhibition for 50 μM (n = 8), 20 μM (n = 3), 10 μM (n = 4) and 5 μM DP (n = 4). D, Immunoblot of TMEM16A protein in SW620 cells. Null FRT cells serves as negative control.