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. 2015 Dec 18;10(12):e0145286. doi: 10.1371/journal.pone.0145286

Fig 4. In vivo effects of retinoic acid on early mouse embryogenesis.

Fig 4

(A) Scheme illustrating the experimental timeline during which pregnant mice received intravenous injection of 25 mg/kg RA at E5.5, E6.5, E7.5, E8.5 or E9.5. Mice were sacrificed on E10.5, E13.5 or E14.5 and macroscopic effects on uteri and embryo development were determined. (B) Representative images of morphological changes observed in embryos in the uteri of mice that were treated with RA (+) or not (-) at the indicated stages and examined at E10.5. ND, not detected. (C) Representative images of morphological changes observed in embryos in the uteri of mice that were treated with RA at E8.5 and examined at E13.5, or treated at E9.5 and examined at E14.5.