TABLE 2.

Enrichment analysis^a

Pathway or function	GO IDb	Differentially expressed proteins	P valuec	No. of differentially expressed proteins
KEGG pathway
Carbon metabolism	1200	PG2124, PG1278, PG1417, PG1190, PG0548, PG1755, PG1812, PG1809	0.0000230*	8
Microbial metabolism in diverse environments	1120	PG1417, PG1278, PG1190, PG2124, PG1755, PG0429, PG1809, PG1812	0.0001170*	8
Citrate cycle (TCA)	20	PG1417, PG0429, PG1809, PG1812	0.0022100*	4
Metabolic pathways	1100	PG1417, PG1232, PG1278, PG1190, PG1803, PG2124, PG1755, PG1764, PG2141, PG0669, PG0429, PG1809, PG1912	0.0062200*	13
Fatty acid biosynthesis	61	PG1764, PG2141	0.0466900*	2
Methane metabolism	680	PG1190, PG1278, PG1803	0.0507000	3
Glycolysis/gluconeogenesis	10	PG2124, PG1755	0.1990000	2
Glycine, serine, and threonine metabolism	260	PG1278, PG1190	0.2159000	2
Biosynthesis of amino acids	1230	PG2124, PG1278, PG1755	0.2159000	3
Fatty acid metabolism	1212	PG1764, PG2141	0.5110000	2
GO molecular functions
Cysteine-type endopeptidase activity	0004197	PG2024, PG1844, PGN_1970, PG0506	0.0202000*	4
Oxidoreductase activity	0016491	PG1545, PG2124, PG1190, PG1232, PG0429, PG1809, PG1812, PG0304	0.0395000*	8
Cysteine-type peptidase activity	0008234	PG2024, PG1844, PGN_1970, PG0506	0.0395000*	4
Oxidoreductase activity, acting on the aldehyde or oxo group of donors	0016903	PG2124, PG0429, PG1809	0.0439900*	3
Unknown molecular function	0003674	PG1545, PG0343, PG1755, PG2124, PG1764, PG2141, PGN_1023, PG0185, PG1190, PG1232, PG1417, PG2024, PG1803, PG1278, PG1297, PGN_1970, PG0506, PG0314, PG0669, PG1844, PG0181, PG0304, PG1328, PG0429, PG1809, PG1812	0.0563000	26
Catalytic activity	0003824	PG1545, PG0343, PG1755, PG2124, PG1764, PG2141, PGN_1023, PG1190, PG1232, PG1417, PG2024, PG1803, PG1278, PG0506, PGN_1970, PG0669, PG1844, PG0304, PG0429, PG1809, PG1812	0.2540000	21
Endopeptidase activity	0004175	PG0506, PGN_1970, PG1844, PG2024	0.3521000	4
Lyase activity	0016829	PG1417, PG0343, PG1755, PG0669	0.3549000	4

^aCarried out by using the STRING database to detect enrichment of proteins in P. gingivalis metabolic pathways with sapienic acid-induced treatment.

^bID, identification number.

^cP values were computed by STRING using a hypergeometric test with Bonferroni multiple comparisons. All probabilities were calculated using a 5% level of significance. Asterisks indicate a 5% level of statistical significance.