FIG 2.

Domain organization of predicted c-di-GMP and c-di-AMP metabolizing proteins in S. venezuelae and S. coelicolor. S. venezuelae and S. coelicolor encode an overlapping set of GGDEF, EAL, HD-GYP, and DAC domain proteins, with minor modifications. SVEN_0451 is unique to S. venezuelae. SCP1.113, SCO1398, and SCO1397 orthologs are not present in S. venezuelae. Predicted signaling domains (GAF, PAS, and PAC) and transmembrane helices (TM) as well as linker regions are shown in gray. Missing residues in SVEN_4873 are shown as a dashed line, and the helix-hairpin-helix domain (HhH) of DisA is indicated.