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Frequency of occurrence of genes encoding intact GGDEF/EAL domain proteins in the genomes of 61 E. coli strains. Mutations in the alleles that do not count as fully intact are described in detail in Table 2. (A) Diguanylate cyclases. (B) c-di-GMP-specific phosphodiesterases. (C) Degenerate GGDEF/EAL domain proteins. An asterisk denotes an allele of pdeG (ycgG) with a 5′ deletion that nevertheless produces an N-terminally truncated yet apparently active PDE (Table 2; see also the text).
