Figure 6.

Results from fibril stretch at the insertion site (a(i), b(i) and c(i)) and midsubstance (a(ii), b(ii) and c(ii)) and fibril sliding at both locations (a(iii), b(iii) and c(iii)) are shown for each group. (a) The wild-type group exhibited an initial hold followed by an increase to 5% applied strain at the insertion site and a monotonic fibril stretch to peak at 3% applied strain at the midsubstance. Fibril sliding occurred in the insertion site from 1 to 3% applied strain. (b) The heterozygous group exhibited the same response as the wild-type group at the insertion site but earlier fibril strain at the midsubstance and significant fibril sliding at both locations throughout the test. (c) The null group exhibited an earlier response of fibril strain at the insertion site and a monotonic increase in strain following an initial reduction in strain at the midsubstance. No significant fibril sliding occurred in either of the null locations. Data are reported at median ± interquartile range. (Online version in colour.)