Table 1.

Summary of key parameters. Data are presented at mean ± s.d. for all parameters except initial d-period and variance, which are presented as median ± interquartile range.

	body weight (g)	area (mm2)	maximum stress (MPa)	stress relaxation (%)	cycles to failure
WT	30.3 ± 3.7a,b	0.13 ± 0.03a,b	34.6 ± 9.9a	35.5 ± 6.1	5336 ± 2849b
HET	28.7 ± 3.0a	0.12 ± 0.02a	33.2 ± 11.5a	39.5 ± 6.0	3117 ± 2068
NULL	18.2 ± 2.6	0.10 ± 0.03	13.9 ± 3.9	50.4 ± 9.9	1988 ± 1436
	dynamic modulus (MPa)	tangent delta	tangent stiffness (N mm–1)	peak cyclic strain (%)	hysteresis (MPa mm mm–1)
WT	194.8 ± 65.2a	0.04 ± 0.01a	17.8 ± 1.3a,b	1.4 ± 0.2	0.03 ± 0.01a
HET	160.4 ± 89.3	0.05 ± 0.01a	18.7 ± 1.6a	1.4 ± 0.1a	0.03 ± 0.008a
NULL	118.1 ± 52.0	0.06 ± 0.01	10.6 ± 1.3	1.5 ± 0.2	0.008 ± 0.003
	transition strain (%)	transition stress (MPa)	toe modulus (MPa)	linear modulus (MPa)	initial d-period (nm)
WT
INS	5.3 ± 1.9	2.7 ± 1.5a	115.6 ± 64.9a	887.0 ± 435.3a,b	61.7 ± 2.7b
MID	4.3 ± 2.4	2.3 ± 1.8	122.3 ± 80.1a,b	713.7 ± 488.13a	62.0 ± 2.5b
HET
INS	4.8 ± 1.3	1.8 ± 1.0	95.0 ± 46.4	616.9 ± 234.6a	62.5 ± 3.7a
MID	5.0 ± 2.0	1.9 ± 2.0	66.5 ± 68.6	549.3 ± 309.1a	61.3 ± 2.9a
NULL
INS	5.0 ± 2.0	1.2 ± 1.0	53.1 ± 37.9	315.4 ± 183.5	62.0 ± 3.0
MID	5.5 ± 3.6	1.2 ± 1.0	41.8 ± 29.1	250.1 ± 106.4	62.2 ± 2.7
	toe region re-alignment	linear region re-alignment	strain required to full re-align (%)	amount of re-alignment	initial variance (nm2)
WT
INS	1.1 ± 0.7	0.9 ± 0.5a,b	5.2 ± 1.5	4.1 ± 1.4a	2.2 ± 1.0
MID	0.7 ± 0.7	0.5 ± 0.5a	5.9 ± 2.1a	2.4 ± 0.8	2.5 ± 1.6
HET
INS	0.9 ± 0.5	0.4 ± 0.5	5.5 ± 1.6	3.8 ± 1.1	4.3 ± 2.5
MID	0.9 ± 0.8	0.7 ± 0.8	5.4 ± 1.5a	2.2 ± 1.0	2.9 ± 1.0
NULL
INS	0.5 ± 0.9	0.2 ± 1.1	4.9 ± 1.6	2.7 ± 1.0	3.1 ± 1.2
MID	0.5 ± 1.0	0.2 ± 0.4	3.6 ± 1.4	2.6 ± 1.2	2.9 ± 2.0

^ap < 0.05 with NULL.

^bp < 0.05 with HET.