Fig 1. Functional classification of proteins regulated in Paracoccidioides upon hypoxia obtained by NanoUPLC-MSE data.
Biological processes of differentially expressed proteins (up- and down-regulated) in Paracoccidioides, Pb01, submitted to 12 and 24 h of hypoxia are shown. The biological processes were obtained using the Pedant on MIPS (http://pedant.helmholtz-muenchen.de/pedant3htmlview/pedant3view?Method=analysis&Db=p3_r48325_Par_brasi_Pb01) and Uniprot databases (http://www.uniprot.org/). One hundred and thirty four and 154 proteins were differentially expressed in 12 and 24 h under hypoxia, respectively, compared with normoxia. In 12 h, 67 proteins were induced and the same number repressed while in 24 h, 102 proteins were induced and 52 were repressed under the same conditions.