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. 2015 Dec 10;9(12):e0004282. doi: 10.1371/journal.pntd.0004282

Fig 3. Overview of metabolic responses of the Paracoccidioides upon hypoxia.

Fig 3

The figure summarizes the data from proteomic analysis and shows the main changes in Paracoccidioides Pb01 metabolism during hypoxia, for 12 and 24 h. Up-regulated proteins detected at both time points are indicated by black, and down-regulated proteins, by grey colours. Proteins are indicated by letters: ACD [long-chain specific acyl-CoA dehydrogenase]; ALDH [aldehyde dehydrogenase]; GLYP [glycogen phosphorylase]; PYC [pyruvate carboxylase]; PDHX [pyruvate dehydrogenase protein X component]; ACL1 [ATP-citrate synthase subunit 1]; ACLY [ATP-citrate lyase]; ACO [aconitate hydratase]; IDH [isocitrate dehydrogenase]; MTND [NADH-ubiquinone oxidoreductase]; COX [cytochrome-c oxidase chain VI]; ATPG [ATP synthase gamma chain]; GPY [glucose-6-phosphate isomerase]; PGAM [2,3-bisphosphoglycerate independent phosphoglycerate mutase]; HBD [3-hydroxybutyryl-CoA dehydrogenase]; FAS1 [fatty acid synthase subunit beta dehydratase]; FAS2 [fatty acid synthase subunit alpha reductase]; GDH [NADP specific glutamate dehydrogenase]; GABD [succinate-semialdehyde dehydrogenase]; ATP1 [ATPase alpha subunit]; ATPB [ATP synthase subunit beta]; F1F0ATP [mitochondrial F1F0 ATP synthase subunit]; ACS [acetyl-coenzyme A synthetase]; FUMA [fumarate hydratase].