Fig 7. PbsrbA is required for hyphal growth under hypoxic conditions.
The A. fumigatus reconstituted strains (PbsrbA), wild type (CEA10) and ΔsrbA were plated on GMM plates and incubated at 37°C under normoxia and hypoxia. The diameter of the colony was measured over 96 h every 24 h and are expressed in inches (cm). Under normoxia, no significant difference in growth speed and colony size could be observed (P ≤ 0.01) except less conidiation in the reconstituted strains (upper panel). In contrast, under hypoxic conditions only the mutant strain (ΔsrbA) did not demonstrate any detectable growth. The reconstituted strains 1, 2 and 3 (Rec1, 2 and 3) and the wild type (CEA10) showed comparable growth; P ≤ 0.01 (lower panel).