Fig 8. Analysis of resistance of the wild type (CEA10), ΔsrbA and the Rec1 strains of A. fumigatus to fluconazole and voriconaloze.

The susceptibility of the Rec1 (PbsrbA), wild type (CEA10) and ΔsrbA of A. fumigatus were analyzed to both drugs, fluconazole and voriconazole. The concentrations of each drug were choose based on previously published data [37]. The fluconazole and voriconazol have no effect on wild type and Rec 1 strains showing that PbsrbA could restore the phenotype of wild type. In contrast, the mutant was susceptible for both drugs, from 1 and 0.012 ug/ ml of fluconazole and voriconazol, respectively.