Table 1. Conserved SREBP pathway in fungi, including Paracoccidioides Pb01, Pb03 and Pb18.
| Homologues (accession numbers a ) of SREBP pathway in Paracoccidioides complex | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Organism | SREBP b | SCAP c | INSIG | Site-2 protease | Dsc proteins (defective for SREBP cleavage) | References | |||
| Paracoccidioides Pb01 | SrbA (XP_002794199) | _ | InsA (XP_002796873) | _ | DscA (EEH40958.2) | _ | DscC (XP_002795148) | DscD (KGQ01980) | In this study. |
| Paracoccidioides Pb03 | SrbA (KGY15961) | _ | InsA (EEH19174) | _ | DscA (EEH21163) | _ | DscC (EEH20878) | DscD (KGY15713) | In this study. |
| Paracoccidioides Pb18 | SrbA (XP_010758341) | _ | InsA (XP_010759317) | _ | DscA (XP_010757140) | _ | DscC (XP_010757528) | DscD (XP_010759941) | In this study. |
| Aspergillus fumigatus | SrbA (XP_749262) | _ | InsA (XP_752057) | _ | DscA (XP_752576) | DscB (XP_751662) | DscC (XP_751757) | DscD (XP_754780) | [27, 37, 38, 45]. |
| Schizosaccharomyces pombe | Sre 1(NP_595694) | Scp1 (NP_596673) | Ins1 (NP_587813) | _ | Dsc1 (NP_595266) | Dsc2 (NP_594090) | Dsc3 (NP_593622) | Dsc4 (NP_594964) | [27, 33, 86, 87]. |
| Ser 2 (NP_595229) | |||||||||
| Cryptococcus neoformans | Sre 1 (XP_567526) | Scp1 (XP_569410) | _ | Stp1 (XP_571333) | _ | _ | _ | _ | [27, 35, 36, 38, 99]. |
a NCBI (http://www.ncbi.nlm.nih.gov/) reference sequence accession number (s).
b Sterol regulatory element binding proteins.
c SREBP cleavage activating protein.