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. 2015 Dec 11;10:7397–7412. doi: 10.2147/IJN.S92697

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© 2015 Yin et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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Cytotoxicity and apoptosis assay of MDA-MB-231 cells incubation with different formulations.

Notes: (A) Viability of MDA-MB-231 cells after incubation with different formulations at different concentrations after 24 hours. The values are represented as mean ± SD (n=5). *P<0.01 versus Taxol^®, **P<0.05 versus PTX-HSA. (B) Different counts of apoptosis and necrotic cells after treatment with different formulations. *P<0.01. (C) Representative results of Annexin V-FITC/PI double labeling assay. Cells were treated with saline (a), PTX-PEG-HSA (b), PTX-HSA (c), or Taxol^® (d) for 24 hours. Early apoptosis (AnnexinV+/PI−), late apoptosis and necrotic cells (AnnexinV+/PI+) are shown.

Abbreviations: PTX, paclitaxel; PEG, polyethylene glycol; HSA, human serum albumin; SD, standard deviation; PI, propidium iodide; FITC, fluorescein isothiocyanate.