Table 1.
Physicochemical characteristics of PTX-PEG-HSA and PTX-HSA nanosuspension
| Groups | DL (wt%)a | EE (%)a | Size (nm) | PDIb | Zeta potential (mV) | pH | OP (mOsm/kg)c |
|---|---|---|---|---|---|---|---|
| PTX-PEG-HSA | 9.1±0.2 | 90.5±0.6 | 123.0±2.1 | 0.11 | −43.6±1.8 | 7.3±0.1 | 322±4.2 |
| PTX-HSA | 9.2±0.1 | 91.4±0.5 | 137.2±1.9 | 0.14 | −39.9±3.2 | 7.3±0.2 | 325±6.2 |
Notes:
a
Mean diameters of the nanosuspensions, detected by DLS.
b
Polydispersity index (PDI) of the nanosuspensions, detected by DLS.
c
Osmotic pressure (OP) of the nanosuspensions.
Abbreviations: PTX, paclitaxel; PEG, polyethylene glycol; HSA, human serum albumin; DLS, dynamic light scattering; DL, drug loading; EE, encapsulation efficiency.