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. Author manuscript; available in PMC: 2016 Jul 1.
Published in final edited form as: Mol Neurobiol. 2015 Jun 21;53(5):3477–3493. doi: 10.1007/s12035-015-9295-y

Figure 10. Increased duration of status epilepticus following acute kainate challenge in MMP-9−/− mice.

Figure 10

(A) Representative example of ECoG recording (top) and power spectral analysis (bottom) of seizure initiation (arrow) identified by increase (2 standard deviations above average) in spiking frequency (top), power of theta frequency (4–8 Hz), and power of gamma frequency (30–60 Hz) (B) ECoG recording (top) and (power spectral analysis (bottom) from representative WT and MMP-9−/− (KO) mouse prior to kainate (baseline), and 30 minutes after kainate challenge (seizure). (C) Quantification of mean seizure duration for 0–60 min (top) and 61–120 min (bottom) following acute kainate challenge. *p<0.05; Student’s T-test. (D) Behavioral analysis of response to acute kainate challenge. Racine scoring was performed every 5 min for 2hr, with observer blind to genotype. (E) Seizure scores of 0–60 min (top) and 61–120 min (bottom) following acute kainate challenge (n=7, 8 subjects for WT and KO, respectively, **p<0.001, Student’s T-test).

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