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. Author manuscript; available in PMC: 2016 Jul 1.
Published in final edited form as: Mol Neurobiol. 2015 Jun 21;53(5):3477–3493. doi: 10.1007/s12035-015-9295-y

Figure 8. Enhanced spontaneous neuronal activity in MMP-9−/− cortex.

Figure 8

(A) Raster plots of spontaneous output of single neurons (100 sweeps of 1 second observations) in WT and MMP-9−/− (KO) mouse. (B) Significant reduction in inter-spike intervals of spontaneous cortical activity in MMP-9−/− (KO) mice relative to WT (*p=0.047, K-S test). Inset: Significant increase in average rate of spontaneous activity in MMP-9−/− (KO) relative to WT (inset; n=9 subjects for WT, 6 subjects for KO; **p=0.02, Student’s T-test). All single unit recordings were acquired from layer IV of primary visual cortex in awake subjects. (C) Power-spectrum density (PSD) analysis of spontaneous EcoG recordings for frequencies ranging from delta to gamma (n=28 recordings from 7 subjects for WT and KO. *p<0.05, Multivariate analysis of variance (MANOVA) for delta; f=7.014, p=0.011; theta; f=9.587, p=0.003; and gamma; f=14.003, p=0.000).

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