Figure 9. Increased c-fos expression following acute kainate challenge in MMP-9−/− mice.
(A) Representative immunostaining for c-fos in P150 WT and MMP-9−/− (KO) mouse hippocampus, control and 2 hours after acute kainate challenge. (B) Quantification of the number of c-fos+ neurons in all hippocampal subfields. (C) Quantification of the intensity of c-fos staining. Control and 2 hr after acute kainate challenge (n=6 subjects). One-way ANOVA, F(4,23)=137.5, p<0.001 for neuron number, F(4,23)=4.698, p=0.012 for intensity. *p<0.05 WT-KA vs. KO-KA Tukey-Kramer post hoc.