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. Author manuscript; available in PMC: 2017 Jul 1.
Published in final edited form as: Neuropharmacology. 2015 Jun 21;106:13–19. doi: 10.1016/j.neuropharm.2015.04.011

Diagram 1.

Diagram 1

The neural pathways and cellular mechanisms activated by histamine in the control of thermogenesis. The neural pathway scheme controlling thermogenesis was adapted from (Morrison, 2011). GABAergic neurons in the MnPOA tonically inhibit sympathetic premotor neurons in the rostral raphe pallidus. Histamine reduces the firing rates of GABAergic MnPO neurons. This results in stimulation of the sympathetic output system. Activation of H1 and/or H2 receptors expressed by glutamatergic MnPO, MPON, or DMH neurons, increase firing rates and stimulates the sympathetic neuron system.