Table 1.
Consistency of lineage analysis results with alternative hypotheses.
| Lineage tracing result | Consistent with hypothesis? |
|||
|---|---|---|---|---|
| CESC-cf | CESC-cp | LESC-cc | LESC-iq | |
| Most labelled clones were short lived | + | + | + | + |
| Long-lived clones all emerged at the periphery | − | − | + | + |
| Stripes extended towards the centre | − | + | + | + |
| Significant numbers of both CC and LC stripes were present soon after stripes emerged | ± | ± | − | + |
| The distance between the limbus and CC stripes did not decrease with chase time | − | + | −* | + |
| The frequency of LC stripes labelled at 12 weeks did not increase and was 35–55% at all chase times | − | + | −* | + |
| Few stripes extended completely to the centre even after long chase times | + | + | + | + |
| Some stripes were discontinuous | + | + | + | + |
| The distance of the central stripe end from the limbus varied widely at all chase times | + | + | − | + |
| Stripe frequency varied with age at labelling. | + | + | + | + |
| The proportion of LC stripes varied with age at labelling | + | + | −* | + |
+, results are consistent with hypothesis.
±, results are not expected but could be consistent with hypothesis if specific assumptions are made.
−, results are not consistent with hypothesis.
*, inconsistent with LESC-cc hypothesis because it predicts all stripes should be LC stripes.
Abbreviations:
CESC-cf Corneal epithelial stem cell hypothesis with centrifugal movement.
CESC-cp Corneal epithelial stem cell hypothesis with centripetal movement.
LESC-cc Limbal epithelial stem cell hypothesis with continuously slow cycling stem cells.
LESC-iq Limbal epithelial stem cell hypothesis with intermittent quiescence.