Table 3.

Univariable and multivariable analysis of potential prognostic factors for survival after diagnosis of recurrent esophageal carcinoma

	HR	95 % CI	p-Valuea	HR	95 % CI	p-Valueb
Age (years)	1.02	1.00–1.04	0.055	1.00	0.99–1.02	0.670
Neoadjuvant therapy
None	Reference	–	–	Reference	–	–
Chemotherapy	1.39	0.98–1.99	0.067	1.02	0.70–1.49	0.936
Radiotherapy	3.45	0.47–25.23	0.222	7.85	0.99–62.54	0.052
Chemoradiation	1.26	0.82–1.94	0.297	0.84	0.50–1.41	0.512
Histological type
Adenocarcinoma	Reference	–	–
Squamous cell carcinoma	1.24	0.84–1.84	0.272
Other	1.10	0.15–7.93	0.922
pT stage
T0	Reference	–	–	Reference	–	–
T1–2	0.47	0.21–1.06	0.067	0.60	0.25–1.41	0.243
T3–4	0.70	0.34–1.45	0.341	0.78	0.34–1.76	0.545
pN stage
N0	Reference	–	–	Reference	–	–
N1	1.80	1.18–2.75	0.007	1.50	0.95–2.37	0.080
N2–3	1.35	0.91–1.99	0.131	1.10	0.70–1.73	0.689
Radicality
R0	Reference	–	–
R1	1.20	0.81–1.77	0.363
Type of recurrence
Locoregional	Reference	–	–	Reference	–	–
Distant	2.10	1.30–3.41	0.003	2.15	1.27–3.65	0.005
Combined	2.54	1.55–4.16	<0.001	1.58	0.89–2.81	0.120
Number of locations
1	Reference	–	–	Reference	–	–
2–3	1.21	0.81–1.79	0.357	1.30	0.83–2.00	0.250
>3	2.20	1.46–3.32	<0.001	2.42	1.34–4.34	0.003
Time to recurrence (months)	0.98	0.96–1.00	0.013	0.99	0.98–1.01	0.263
Treatment of recurrence
Best supportive care	Reference	–	–	Reference	–	–
Treatment focused on tumor reduction	0.27	0.19–0.38	<0.001	0.29	0.20–0.44	<0.001

Analysis was performed using a Cox regression model

Bold values indicate statistically significant (e.g. p < 0.05). All variables with a p value <0.2 from univariable analysis were used for multivariable analysis

HR hazard ratio, CI confidence interval

^aUnivariable analysis

^bMultivariable analysis