Table 2.
Reference list for in vivo fluorescence imaging in living mouse model.
| Mouse model | Reagents and application for in vivo visualization of SPs or NFTs | Fluorescence reporters for in vivo visualization of AD pathophysiology | References |
|---|---|---|---|
| PDAPP (APP V717F) | Thioflavin S, anti-Ab w/Fluorescein (intracerebral injection) | Bacskai et al., 2001 | |
| Tg2576 (APPsw) | Thioflavin S, anti-Ab (10D5) conjugated Cy3 (intracerebral injection) | Christie et al., 2001 | |
| PS-APP (PS1M146L vs. Tg2576) | Methoxy-X04 (i.p.) | Klunk et al., 2002 | |
| PDAPP Tg2576 PS-APP | Thioflavin T, Thioflavin S, PiB (i.v.) | Bacskai et al., 2003 | |
| Tg2576 | Methoxy-X04 (i.p.) | Robbins et al., 2006 | |
| PS1dEx9/APPsw | curcumin (i.v.) Methoxy-X04 (i.p.) |
Garcia-Alloza et al., 2007 | |
| PS1L166P/APPsw | Methoxy-X04 (i.p.) | Hefendehl et al., 2011 | |
| 3xTg-AD APPdutch/iowa Tg2576 | – | fluo-4 AM | Takano et al., 2007 |
| PS1dEx9/APPsw | Methoxy-X04 (i.p.) | YC3.60 camereon (AAV, intracerebral injection) | Kuchibhotla et al., 2008 |
| PS45(PS1G384A)/APP23(sw) | Thioflavin S (intracerebral injection) | Oregon green BAPTA | Busche et al., 2008 |
| PS1dEx9/APPsw | Methoxy-X04 (i.p.) | Oregon green BAPTA SR-101 for astrocyte | Kuchibhotla et al., 2009 |
| PS45/APP23 | Thioflavin S (intracerebral injection) | Fluo-8 AM | Busche et al., 2012 |
| PS1dEx9/APPsw | Methoxy-X04 (i.p.) | CaMKII 5′UTR-EGFP/Venus-3'UTR (AAV, intracerebral injection) | Meyer-Luehmann et al., 2009 |
| PS1dEx9/APPsw | Methoxy-X04 (i.p.) | Crossbreeding to Arc/dVenus mice | Rudinskiy et al., 2012 |
| Tg2576 | Methoxy-X04 (i.p.) | Crossbreeding to B6C3-YFP mice Crossbreeding to Cx3CR1/GFP mice | Meyer-Luehmann et al., 2008 |
| PDAPP | Methoxy-X04 (i.p.) | Crossbreeding to Cx3CR1 mice | Koenigsknecht-Talboo et al., 2008 |
| rTg4510 (Tau P301L) | Thioflavin S (intracerebral injection) | FLICA (intracerebral injection) | Spires-Jones et al., 2008 |
| rTg4510 (Tau P301L) | Thiopflavin S (intracerebral injection) X-34 (i.v.) | FLICA (intracerebral injection) | de Calignon et al., 2010 |
| PS19 (Tau P301S) | PBB3 (i.p., i.v.) | Maruyama et al., 2013 | |
| rTg4510 (Tau P301L) | Thioflavin S (intracerebral injection) | YC3.60 camereon (AAV, intracerebral injection) | Kopeikina et al., 2013 |
| rTg4510 (Tau P301L) | Thioflavin S (intracerebral injection) | YC3.60 camereon (AAV, intracerebral injection) | Kuchibhotla et al., 2014 |