Table 4.

Distribution of ESR1 four-locus haplotype frequencies as estimated through expectation-maximisation algorithms

Locus				Proportion
c.454-397C→T	c.454-351A→G	c.729C→T	c.975C→G	Controls (n = 1511)	Ductal cases (n = 1148)	Lobular cases (n = 184)
T	A	C	C	0.369	0.404	0.373
C	G	C	C	0.285	0.267	0.276
C	A	C	C	0.114	0.117	0.125
T	A	C	G	0.123	0.117	0.123
C	G	C	G	0.058	0.049	0.076
T	A	T	G	0.032	0.027	0.021
Proportion accounted for by the above most common haplotypes:				0.981	0.981	0.994