Table 3.
Odds ratios (ORs) for breast cancer in relation to CYP1A1 genotypes, according to menopausal status (African-American and white women combined)
| Premenopausal | Postmenopausal | |||||
| Cases (n = 352) | Controls (n = 321) | OR (95% CI)a | Cases (n = 336) | Controls (n = 381) | OR (95% CI)a | |
| M1 locus | ||||||
| wt/wt | 242 | 221 | Reference | 240 | 269 | Reference |
| M1/wt | 88 | 87 | 1.0 (0.7–1.4) | 83 | 98 | 0.9 (0.7–1.3) |
| M1/M1 | 15 | 11 | 1.2 (0.6–2.8) | 10 | 9 | 1.2 (0.5–3.0) |
| M1/wt or M1/M1 | 103 | 98 | 1.0 (0.7–1.4) | 93 | 107 | 1.0 (0.7–1.3) |
| Missing | 7 | 2 | 3 | 5 | ||
| M2 locus | ||||||
| wt/wt | 329 | 294 | Reference | 315 | 358 | Reference |
| M2/wt | 21 | 25 | 0.7 (0.4–1.3) | 20 | 23 | 1.0 (0.6–1.9) |
| M2/M2 | 2 | 2 | 0.9 (0.1–6.3)b | 1 | 0 | nd |
| M2/wt or M2/M2 | 23 | 27 | 0.7 (0.4–1.3) | 21 | 23 | 1.1 (0.6–2.0) |
| Missing | 0 | 0 | 0 | 0 | ||
| M3 locus | ||||||
| wt/wt | 327 | 296 | Reference | 303 | 344 | Reference |
| M3/wt | 18 | 20 | 0.9 (0.4–1.8) | 30 | 28 | 1.2 (0.7–2.2) |
| M3/M3 | 0 | 3 | nd | 0 | 4 | nd |
| M3/wt or M3/M3 | 18 | 23 | 0.8 (0.4–1.5) | 30 | 32 | 1.0 (0.6–1.8) |
| Missing | 7 | 2 | 3 | 5 | ||
| M4 locus | ||||||
| wt/wt | 325 | 301 | Reference | 320 | 354 | Reference |
| M4/wt | 27 | 20 | 1.3 (0.7–2.3) | 14 | 27 | 0.6 (0.3–1.1) |
| M4/M4 | 0 | 0 | nd | 2 | 0 | nd |
| M4/wt or M4/M4 | 27 | 20 | 1.3 (0.7–2.3) | 16 | 27 | 0.7 (0.4–1.3) |
| Missing | 0 | 0 | 0 | 0 | ||
CI, confidence interval; wt, wild type; nd, not determined. a Adjusted for age, race, and sampling fractions. b Imprecise estimate.