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. 2015 Dec 22;9:484. doi: 10.3389/fncel.2015.00484

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Copyright © 2015 Fernández-Sánchez, Lax, Campello, Pinilla and Cuenca.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Superficial vascular plexus in SD and P23H rat retinas. Whole-mounted retinas from SD rats (A,C) and P23H rats (B,D–F) at P360 (A,B,E), and P540 (C,D,F), stained for collagen IV (green) and GFAP (red) in order to show the relationship between blood vessels and astrocytes, respectively, during retinal degeneration. During aging, blood vessels in P23H rat retinas (B,D) suffered alterations related to astrocyte changes that were unobserved in SD rats (A,C). Note the formation of blood vessel tangles at P360 (E, arrows) and P540 (F, arrows). Scale bar: 100 μm (A,D), 40 μm (E,F).